Modulation of RNA polymerase activity through the trigger loop folding

 Abstract

Folding of the trigger loop of RNA polymerase promotes nucleotide addition through creating a closed, catalytically competent conformation of the active center. Here, we discuss the impact of adjacent RNA polymerase elements, including the F loop and the jaw domain, as well as external regulatory factors on the trigger loop folding and catalysis.

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89 - 94
doi
10.4161/trns.1.2.12544
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Modulation of RNA polymerase activity through the trigger loop folding