No human protein is exempt from bacterial motifs, not even one

 Abstract

The hypothesis that mimicry between a self and a microbial peptide antigen is strictly related to autoimmune pathology remains a debated concept in autoimmunity research. Clear evidence for a causal link between molecular mimicry and autoimmunity is still lacking. In recent studies we have demonstrated that viruses and bacteria share amino acid sequences with the human proteome at such a high extent that the molecular mimicry hypothesis becomes questionable as a causal factor in autoimmunity. Expanding upon our analyses, here we detail the bacterial peptide overlapping to the human proteome at the penta-, hexa-, hepta-, and octapeptide levels by exact peptide matching analysis, and demonstrate that

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Pages
328 - 334
doi
10.4161/self.1.4.13315
Type
Report
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No human protein is exempt from bacterial motifs, not even one