A-to-I RNA Editing and Human Disease

 Abstract

The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information. As the molecular players of editing are characterized and an increasing number of genes become identified that are subject to A-to-I modification, the potential impact of editing on the etiology or progression of human diseases is realized. Here we review the recent knowledge on where disturbances in A-to-I RNA editing have been correlated with human disease phenotypes.

Full Text Options
Article
Metrics
 Share
 Info
Pages
1 - 9
doi
10.4161/rna.3.1.2495
Type
Review
 Metrics
 Cite This Article
 Permissions
 Permissions
 Reprints
A-to-I RNA Editing and Human Disease