MicroRNA-9: Functional evolution of a conserved small regulatory RNA

 Abstract

The functional significance of microRNA-9 (miR-9) during evolution is evidenced by its conservation at the nucleotide level from flies to humans but not its diverse expression patterns. Recent studies in several model systems reveal that miR-9 can regulate neurogenesis through its actions in neural or non-neural cell lineages. In vertebrates, miR-9 exerts diverse cell-autonomous effects on the proliferation, migration, and differentiation of neural progenitor cells by modulating different mRNA targets. In some developmental contexts, miR-9 suppresses apoptosis and is misregulated in several types of cancer cells, influencing proliferation or metastasis formation. Moreover, downregulation of miR-9 in postmitotic neurons is also implicated in some neurodegenerative diseases. Thus, miR-9 is emerging as an important regulator in development and disease through its ability to modulate different targets in a manner dependent on the developmental stage and the cellular context.

Full Text Options
Article
Metrics
 Share
 Full Text
 Info
Pages
557 - 564
doi
10.4161/rna.8.4.16019
Type
RNA Families
 Metrics
 Cite This Article
 Permissions
 Permissions
 Reprints
MicroRNA-9: Functional evolution of a conserved small regulatory RNA