The ups and downs of miR-205: Identifying the roles of miR-205 in mammary gland development and breast cancer

 Abstract

Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.

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Pages
300 - 304
doi
10.4161/rna.7.3.11837
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Point-of-View
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The ups and downs of miR-205: Identifying the roles of miR-205 in mammary gland development and breast cancer