Gene loops and HDACs to promote transcription directionality

 Abstract

Gene loops have been described in different organisms from yeast to human and form through interaction between components of the transcription pre-initiation complex and Ssu72, a member of the 3′ end cleavage and polyadenylation complex. A recent study by Tan-Wong et al. reports a new role for gene loops in promoting ORF transcription directionality from otherwise bidirectional promoters.

 Commentary to: 

SM Tan-Wong, JB Zaugg, J Camblong, Z Xu, DW Zhang, HE Mischo, AZ Ansari, NM Luscombe, LM Steinmetz, NJ Proudfoot. Gene loops enhance transcriptional directionality. Science 2012; 338: 671- 5.
PMID: 23019609 DOI: 10.1126/science.1224350

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92 - 94
doi
10.4161/nucl.24236
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Commentary
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Gene loops and HDACs to promote transcription directionality