Genetic control of programmed cell death (apoptosis) in Drosophila

 Abstract

Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies, and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.

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Pages
78 - 90
doi
10.4161/fly.3.1.7800
Type
Review
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Genetic control of programmed cell death (apoptosis) in Drosophila