Epigenetics: The epicenter of the hypoxic response

 Abstract

It is becoming increasingly apparent that epigenetics plays a crucial role in the cellular response to hypoxia. Such epigenetic regulation may work hand in hand with the hypoxia-induced transcription factor (HIF) family or may contribute in a more substantial way to the maintenance of a hypoxia-adapted cellular phenotype long after HIF has initiated the immediate response pathways. In this article we discuss the current research implicating epigenetic mechanisms in the cellular response to hypoxic environments. This includes; the role of epigenetics in both the stabilization and binding of HIF to its transcriptional targets, the role of histone demethylase enzymes following direct HIF transactivation, and finally, the impact of hypoxic environments on global patterns of histone modifications and DNA methylation.

Full Text Options
Article
Metrics
 Share
 Info
Pages
293 - 296
doi
10.4161/epi.5.4.11684
Type
Point-of-View
 Metrics
 Cite This Article
 Permissions
 Permissions
 Reprints
Epigenetics: The epicenter of the hypoxic response