Epidemiologic evidence for supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism

 Abstract

This study examines whether maternal vitamin D deficiency is a risk factor for infantile autism disease (IAD). We used epidemiologic data seasonal variation of birth rates and prevalence of IAD for cohorts born before 1985. For seven studies reporting spring-to-summer excess birth rates for IAD, the season progressed from broad near 30° N latitude, spring/summer in midlatitudes, to winter at the highest latitude. Also, using data from 10 studies, we found a strong effective latitudinal (related to wintertime solar ultraviolet B radiation) increase in IAD prevalence. These findings are consistent with maternal vitamin D deficiency’s being a risk factor for IAD, possibly by affecting fetal brain development as well as possibly by affecting maternal immune system status during pregnancy,.  Further investigation of this hypothesis is warranted.

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Pages
223 - 228
doi
10.4161/derm.1.4.9500
Type
Report
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Epidemiologic evidence for supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism