The principal action of growth hormone – releasing hormone (GHRH) is considered to be the stimulation of GH production and release in the pituitary1. With the recent identification of wound –associated fibroblasts as a direct target of GHRH2, this neuropeptide emerges as a rather pleiotropic hormone implicated in the regulation of various physiological and pathological processes and affecting diverse cell types.
N Dioufa, AV Schally, I Chatzistamou, E Moustou, NL Block, GK Owens, AG Papavassiliou, H Kiaris. Acceleration of wound healing by growth hormone-releasing hormone and its agonists. Proc Natl Acad Sci U S A 2010; 107: 18611- 5.
PMID: 20937882 DOI: 10.1073/pnas.1013942