The actin cytoskeleton in presynaptic assembly

 Abstract

Dramatic morphogenetic processes underpin nearly every step of nervous system development, from initial neuronal migration and axon guidance to synaptogenesis. Underlying this morphogenesis are dynamic rearrangements of cytoskeletal architecture. Here we discuss the roles of the actin cytoskeleton in the development of presynaptic terminals, from the elaboration of terminal arbors to the recruitment of presynaptic vesicles and active zone components. The studies discussed here underscore the importance of actin regulation at every step in neuronal circuit assembly.

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Pages
379 - 387
doi
10.4161/cam.24803
Type
Special Focus Review
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The actin cytoskeleton in presynaptic assembly