Extracellular matrix-derived peptides and myocardial repair

 Abstract

Repairing cardiac tissue remains one of the most challenging goals in tissue engineering. Here, we discuss ways whereby we sought to treat myocardial infarctions using extracellular-matrix derived peptides. Using an ischemia/reperfusion myocardial infarction rodent model, we targeted these extracellular matrix-derived peptides to the myocardial infarct site and were able to induce angiogenesis and alter the negative remodeling seen after an acute myocardial infarction. Our results indicate a potentially new strategy for repairing damaged tissue.

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Pages
111 - 113
doi
10.4161/cam.5.2.13796
Type
Commentary & View
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Extracellular matrix-derived peptides and myocardial repair