Exploiting synthetic lethal interactions for targeted cancer therapy

 Abstract

Emerging data suggests that synthetic lethal interactions between mutated oncogenes/tumor suppressor genes and molecules involved in DNA damage signaling and repair can be therapeutically exploited to preferentially kill tumor cells.   In this review, we discuss the concept of synthetic lethality, and describe several recent examples in which this concept was successfully implemented to target tumor cells in culture, in mouse models, and in human cancer patients.

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Pages
3112 - 3119
doi
10.4161/cc.8.19.9626
Type
Review
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Exploiting synthetic lethal interactions for targeted cancer therapy