Paths of FGFR-driven tumorigenesis

 Abstract

Fibroblast growth factor receptors (FGFRs) comprise a subfamily of receptor tyrosine kinases (RTKs) that are master regulators of a broad spectrum of cellular and developmental processes, including apoptosis, proliferation, migration, and angiogenesis. Due to their broad impact, FGFRs and other RTKs are highly regulated and normally only basally active. Deregulation of FGFR signaling by activating mutations or ligand/receptor overexpression could allow these receptors to become constitutively active, leading to cancer development, including both hematopoietic and solid tumors, such as breast, bladder, and prostate carcinomas.  In this review, we focus on potential modes of FGFR-mediated tumorigenesis, in particular, the role of FGFR1 during prostate cancer progression.

Full Text Options
Article
Metrics
 Share
 Full Text
 Info
Pages
580 - 588
doi
10.4161/cc.8.4.7657
Type
Review
 Metrics
 Cite This Article
 Permissions
 Permissions
 Reprints
Paths of FGFR-driven tumorigenesis