Chromosomal Instability in Cancer: Causality and Interdependence

 Abstract

Aberrations in the number and structure of chromosomes are a common feature of cells from solid tumours. In this brief review, I summarize the evidence that there is a causal relationship between chromosomal instability and the initiation or progression of cancer, and argue that the co-existence of both forms of instability in many solid tumours reflects mechanistic and functional interdependencies that remain poorly investigated.

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Pages
2341 - 2343
doi
10.4161/cc.6.19.4753
Type
Spotlight
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Chromosomal Instability in Cancer: Causality and Interdependence