Cohesin and related coiled-coil domain-containing complexes physically and functionally connect the dots across the genome

 Abstract

Interactions between genetic regions located across the genome maintain its three-dimensional organization and function. Recent studies point to key roles for a set of coiled-coil domain-containing complexes (cohibin, cohesin, condensin and monopolin) and related factors in the regulation of DNA-DNA connections across the genome. These connections are critical to replication, recombination, gene expression as well as chromosome segregation.

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Pages
2669 - 2682
doi
10.4161/cc.10.16.17113
Type
Review
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Cohesin and related coiled-coil domain-containing complexes physically and functionally connect the dots across the genome