BRCA1 regulation of base excision repair pathway

 Abstract

This feature item briefly reviews the relation of the tumor suppressor function of BRCA1 with DNA damage and repair. The main focus of this article is on the regulation of base excision repair (BER) pathway by BRCA1 and in that context we introduce poly (ADP-ribose) polymerase 1 (PARP-1), which is a key enzyme in BER pathway, and its possible regulation by BRCA1.

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Pages
2471 - 2472
doi
10.4161/cc.9.13.12084
Type
Editorials: Cell Cycle Features
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BRCA1 regulation of base excision repair pathway