RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis

 Abstract

When the levels of intracellular amino acids are high, RRAG GTPases recruit MTORC1 to lysosomes and promote its activation. We found that RRAGs also recruit specific MTORC1 substrates to the lysosomal surface, thus facilitating MTORC1-mediated phosphorylation and regulation. In particular, active RRAGs interact with the transcription factor EB (TFEB), the master regulator of a gene network that promotes lysosomal biogenesis and autophagy. Redistribution to lysosomes is critical for MTORC1-dependent inactivation of TFEB under nutrient-rich conditions. Therefore, RRAGs play a critical role coordinating nutrient availability and cellular clearance.

 Related Article:

JA Martina, R Puertollano. Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes. J Cell Biol 2013; 200: 475- 91.
PMID: 23401004 DOI: 10.1083/jcb.201209135

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Pages
928 - 930
doi
10.4161/auto.24371
Type
Autophagic Punctum
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RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis