Autophagy across the eukaryotes: Is S. cerevisiae the odd one out?

 Abstract

Autophagy is conserved throughout the eukaryotes and for many years, work in Saccharomyces cerevisiae has been at the forefront of autophagy research. However as our knowledge of the autophagic machinery has increased, differences between S. cerevisiae and mammalian cells have become apparent. Recent work in other organisms, such as the amoeba Dictyostelium discoideum, indicate an autophagic pathway much more similar to mammalian cells than S. cerevisiae, despite its earlier evolutionary divergence. S. cerevisiae therefore appear to have significantly specialized, and the autophagic pathway in mammals is much more ancient than previously appreciated, which has implications for how we interpret data from organisms throughout the eukaryotic tree.

Full Text Options
Article
Metrics
 Share
 Full Text
 Supplemental Material
 Info
Pages
1159 - 1162
doi
10.4161/auto.20527
Type
Views and Commentaries
 Metrics
 Cite This Article
 Permissions
 Permissions
 Reprints
Autophagy across the eukaryotes: Is S. cerevisiae the odd one out?