TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processes

 Abstract

Autophagy is a fundamental catabolic process that plays a central role in health and disease. An efficient autophagic process relies on the cooperation of two distinct types of organelles: the autophagosome and the lysosome. We have identified a gene network that regulates the biogenesis and function of both organelles. Our findings reveal an important role of transcription in the regulation of starvation-induced autophagy, and link lysosomal biogenesis to autophagy.

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C Settembre, Malta C Di, VA Polito, Arencibia M Garcia, F Vetrini, S Erdin, SU Erdin, T Huynh, D Medina, P Colella, M Sardiello, DC Rubinsztein, A Ballabio. TFEB links autophagy to lysosomal biogenesis. Science 2011; 332: 1429- 33.
PMID: 21617040 DOI: 10.1126/science.1204

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Pages
1379 - 1381
doi
10.4161/auto.7.11.17166
Type
Autophagic Punctum
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TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processes