Degradation through the lysosome involves careful orchestration of numerous molecular players in concert. Many of these key molecular players remain to be identified. We find that wild-type presenilins play a key role in degradation through the autophagy-lysosome system by modulating either fusion of autophagosomes to lysosomes or lysosome function.
KM Neely, KN Green, FM LaFerla. Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner. J Neurosci 2011; 31: 2781- 91.
PMID: 21414900 DOI: 10.1523/