Endocytosis has an essential role in adenovirus (Ad) pathophysiology by downregulating receptors engaged in innate immune responses, which permits survival of infected host cells. The early transcription region 3 Ad protein RIDα is a key player in this process. We have discovered that RIDα maintains a functional endocytic apparatus by preventing an excessive autophagic response during an acute infection. Our results also show that ectopic RIDα is sufficient to rescue the abnormal cholesterol storage phenotype in Niemann-Pick type C (NPC) disease fibroblasts. Furthermore, RIDα stabilizes the endocytic pathway by usurping autophagic membranes.
NL Cianciola, CR Carlin. Adenovirus RID-alpha activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C. J Cell Biol 2009; 187: 537- 52.
PMID: 19948501 DOI: 10.1083/jcb.20090303