Larval midgut destruction in Drosophila: Not dependent on caspases but suppressed by the loss of autophagy

 Abstract

While most programmed cell death (PCD) in animal development is reliant upon the caspase-dependent apoptotic pathway and subsequent cleavage of caspase substrates, we found that PCD in Drosophila larval midgut occurs normally in the absence of the main components of the apoptotic machinery. However, when some of the components of the autophagic machinery were disrupted, midgut destruction was severely delayed. These studies demonstrate that Drosophila midgut PCD is executed by a novel mechanism where caspases are apparently dispensable, but that requires autophagy.

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JM Yau, JB Olenczak, JF Dammann, SJ Bensmaia. Temporal frequency channels are linked across audition and touch. Curr Biol 2009; 19: 561- 6.
PMID: 19646879 DOI: 10.1016/j.cub.2009.0

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Pages
163 - 165
doi
10.4161/auto.6.1.10601
Type
Autophagic Punctum
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Larval midgut destruction in Drosophila: Not dependent on caspases but suppressed by the loss of autophagy