The Forkhead Transcription Factors Play Important Roles in Vascular Pathology and Immunology

Chapter Details

Pub Date: 2 Nov 2009
Pages: 16
Chapter Category: Cell Biology
Taken from the Book: Forkhead Transcription Factors: Vital Elements in Biology and Medicine
Book Series: Special Books
Edited by: Kenneth Maiese

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The Forkhead Transcription Factors Play Important Roles in Vascular Pathology and Immunology

Xiao-Feng Yang, Pu Fang, Shu Meng, Michael Jan, Xinyu Xiong, Ying Yin and Hong Wang

About this Chapter

Transcription factor families are a small number of upstream master genes in “higher hierarchy“ that control the expression of a large number of downstream genes. These transcription factors have been found to integrate the signaling pathways underlying the pathogenesis of cardiovascular diseases with or without autoimmune inflammatory mechanisms. In this chapter, we organize our analysis of recent progress in characterization of forkhead (FOX) transcription factor family members in vascular pathology and immune regulation into the following sections: (1) Introduction of the FOX transcription factor superfamily; (2) FOX transcription factors and endothelial cell pathology; (3) FOX transcription factors and vascular smooth muscle cells; and (4) FOX transcription factors, inflammation and immune system. Advances in these areas suggest that the FOX transcription factor family is important in regulating vascular development and the pathogenesis of autoimmune inflammatory cardiovascular diseases.

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