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Research Paper
Seroprevalence of anti Vi antibodies and immunogenicity of Typhim Vi vaccine in children
Divya Gupta, M.M.A. Faridi , Anju Aggarwal and Iqbal Kaur
volume 4 | issue 4
july/august 2008Pages: 305 - 308
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This prospective study was carried out on 250 children between 6 months to 5 years of age to determine seroprevalence of anti Vi antibodies and to measure seroresponse and percent seroconversion to TyphimVi polysaccharide vaccine in children 2-5 years of age. Fifty children each were enrolled between 6 to12 months of age (Group A), between 1- 2 years of age(Group B), between 2-3 years of age(Group C), between 3-4 years of age (Group D) and between 4-5 years of age (Group E). Anti- Vi antibody baseline titres were determined in all children. Children in Groups C to E were vaccinated with Typhim Vi vaccine. Baseline and postvaccination antibody titres were determined by ELISA. Test serum which had antibody levels >1 µg/ml were scored as seropositive. Of 250 children, 3 had base line anti-Vi antibodies >1µg/ml. Following immunization overall seroconversion rate was 77.5% with 65.3%, 78.2% and 88% children showing seroconversion in Groups C, D and E respectively. Seroconversion was significantly more in Group E children compared to Group C (p=0.0148). There were no significant adverse reactions following vaccination. The study highlights very low prevalence of baseline anti Vi antibodies in children between 6 months and less than 5 years of age and shows high immunogenicity and safety of Typhim Vi polysaccharide vaccine in children 2- 5 years of age.
Authors
Divya Gupta
Department of Pediatrics; University College of Medical Sciences; Delhi, India
M.M.A. Faridi
Department of Pediatrics; University College of Medical Sciences; Delhi, India
Anju Aggarwal
Department of Pediatrics; University College of Medical Sciences; Delhi, India
Iqbal Kaur
Department of Pediatrics; University College of Medical Sciences; Delhi, India