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Research Paper

Immunogenicity and reactogenicity of acellular pertussis booster vaccines in children: Standard pediatric versus a reduced-antigen content formulation

Claudius U. Meyer, Pirmin Habermehl, Markus Knuf, Bernhard Hoet, Joanne Wolter and Fred Zepp

Booster vaccination with a reduced-antigen-content dTpa, pediatric DTPa or adult Td vaccine in DTPa-primed children aged 4-6 years was evaluated. Immunogenicity and CMI was assessed one month and 3.5 years after vaccination. Symptoms were solicited for 15 days post-vaccination. There were no differences between groups in diphtheria or tetanus seroprotection or pertussis vaccine-response rates. Anti-diphtheria and anti-PRN concentrations were higher after DTPa, but groups differences reduced over time. Non-significant trends toward reduced reactogenicity of dTpa were observed. Many factors influence vaccine choice at pre-school age. The dTpa vaccine was as immunogenic and possibly better tolerated than DTPa at this age.

Authors

Claudius U. Meyer

Pediatric Immunology & Infectious Diseases; Children’s Hospital; Johannes Gutenberg University of Mainz; Mainz, Germany

Pirmin Habermehl

Pediatric Immunology & Infectious Diseases; Children’s Hospital; Johannes Gutenberg University of Mainz; Mainz, Germany

Markus Knuf

Pediatric Immunology & Infectious Diseases; Children’s Hospital; Johannes Gutenberg University of Mainz; Mainz, Germany

Bernhard Hoet

GlaxoSmithKline Biologicals; Rixensart, Belgium

Joanne Wolter

GlaxoSmithKline Biologicals; Rixensart, Belgium

Fred Zepp

Pediatric Immunology & Infectious Diseases; Children’s Hospital; Johannes Gutenberg University of Mainz; Mainz, Germany