Progress in dendritic cell immunotherapy: Elucidating the enigma of Th-1 polarization
Volume 4, Issue 2
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Pages 162 - 164http://dx.doi.org/10.4161/hv.4.2.5091
Authors: William K. Decker and Elizabeth J. Shpall View affiliations
The goal of harnessing the immune system to effectively eradicate neoplastic disease will require the generation of robust Th-1 type immunity and durable immunological memory against the antigenic repertoire that differentiates normal self from neoplastic self. While the literature presents a very mixed picture as to the requirement of T-cell help for the generation of both primary and memory CTL responses, there appears to be a general consensus that CD4+ T-cell help will be required to generate durable responses against self cancer antigens that are devoid of foreign PAMPs and for which high-affinity T-cell clones have been deleted as a consequence of thymic selection. Here we comment briefly upon the characterization of an emerging regulatory pathway that enhances Th-1 polarization and CD8+ CTL responses by a mechanism dependent upon CD40L-mediated T-cell help. Further, we speculate that the full elucidation of this mechanism might be generally useful in answering some unresolved questions regarding the initiation of Th-1 polarized responses.
Received: September 11, 2007; Accepted: September 26, 2007