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Commentary

Optimisation of Oral Immunization Through Receptor-Mediated Targeting of M Cells

A. Ruth Foxwell, Allan W. Cripps and Jennelle M. Kyd

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Only a small number of oral vaccines are available for routine immunisations despite a significant research effort and a number of obvious advantages over parenteral vaccination. The major roadblock in the development of oral vaccines has been mostly attributed to a lack of ability to specifically target antigen to the mucosal immune system of the gastrointestinal tract. This commentary examines the accessing of M cells through receptor interaction on the apical surface of the cell in order to enhance the efficiency and efficacy of oral immunisation. Three challenges have been identified (i) the availability of appropriate experimental models to study M cell targeting and transcytosis; (ii) appropriate tools for investigating the specificity of targeting; and (iii) the identification of priority targets on the apical surface of M cells.

Authors

A. Ruth Foxwell

University of Canberra, Australian Capital Territory, Australia

Allan W. Cripps

Griffith Health; Griffith University; Queensland, Australia

Jennelle M. Kyd

Griffith University, Queensland, Australia

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.