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Research Paper
Dose-Response Relationship of DNA and Recombinant Fowlpox Virus Prime-Boost HIV Vaccines: Implications for Future Trials
Robert De Rose, Mark T. Sullivan, C. Jane Dale, Anthony D. Kelleher, Sean Emery, David A. Cooper, Ian A. Ramshaw, David B. Boyle and Stephen J. Kent
volume 2 | issue 3
may/june 2006Pages: 134 - 136
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Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpoxvirus HIV vaccines showed that 1 mg of DNA vaccine and 5 x 107 pfu of fowlpoxvirus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in monkeys. These data provide a rationale for guiding dosing in future trials of HIV vaccine technologies.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.