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Research Paper
Safety and Immunogenicity of a Meningococcal (Groups A, C, Y, W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Children Aged 2 to 10 Years in Chile
Rosanna Lagos, Thomas Papa, Alma Muñoz, Robert Ryall, Miriam Pina and Ehab Bassily
volume 1 | issue 6
november/december 2005Pages: 228 - 231
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Immune responses to meningococcal conjugate (Menactra™; MCV-4) and plain polysaccharide (Menomune®-A/C/Y/W-135; PSV-4) vaccines against serogroups A, C, Y, and W-135 were assessed in 220 of 1037 Chilean children aged 2 to 10 years participating in a comparative safety trial. Both vaccines were generally well tolerated. Geometric mean serum bactericidal antibody (SBA) titers 28 days postvaccination were comparable in both groups for all four serogroups. Seroconversion was evident in >97% of MCV-4 and >90% of PSV-4 vaccinees who tested seronegative at baseline. Menactra™ safely induced broad and robust immune responses against serogroups A, C, Y, and W-135 in this population.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.