Special Focus Review

Future therapies for food allergy

Volume 8, Issue 10   October 2012
Pages 1479 - 1484
http://dx.doi.org/10.4161/hv.20868
Keywords: anaphylaxis, desensitization, food allergy, oral immunotherapy, subcutaneous immunotherapy, sublingual immunotherapy, tolerance
Authors: Laurie M. McWilliams, Talal Mousallem and A. Wesley Burks

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Abstract:
Food allergy affects 3.9% of US children and is increasing in prevalence. The current standard of care involves avoidance of the triggering food and treatment for accidental ingestions. While there is no current curative treatment, there are a number of therapeutic strategies under investigation. Allergen specific therapies include oral and sublingual immunotherapy with native food protein as well as recombinant food proteins. Allergen non-specific therapies include a Chinese herbal formula (FAHF-2) and the use of anti-IgE monoclonal antibody therapy. Although none of these treatments are ready for clinical use, these therapeutic strategies present promising options for the future of food allergy.

Received: May 3, 2012; Accepted: May 24, 2012; Published Online: August 16, 2012

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