Research Paper

Comparison of stimulating effect on subpopulations of lymphocytes in human peripheral blood by methionine enkephalin with IL-2 and IFN-γ

Volume 8, Issue 8   August 2012
Pages 1082 - 1089
http://dx.doi.org/10.4161/hv.20759
Keywords: Interferon-γ, Interleukin-2, human peripheral blood, lymphocyte subpopulations, methionine enkephalin
Authors: Hui Hua, Changlong Lu, Weiwei Li, Jingjuan Meng, Danan Wang, Nicolas P. Plotnikoff, Enhua Wang and Fengping Shan

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Abstract:
The aim of this study was to investigate the effects of mechanisms of methionine enkephalin (MENK) on lymphocytes in human peripheral blood. We detected CD4+T cells, CD8+T cells, CD4+CD25+ regulatory T cells (Treg), dendritic cells (DCs), natural killer cells (NK), NKT cells and γδT cells before and after treatment with 10−12M MENK, in cell culture by FCM and RT-PCR. Our findings show that MENK stimulating expansion of lymphocyte subpopulationns by inhibiting CD4+CD25+ regulatory T cells (Treg), which is unique discovery of our study. We may use MENK as a drug to treat cancer patients, whose immune systems are damaged by chemotherapy or radiotherapy.

Received: February 22, 2012; Accepted: May 15, 2012; Published Online: August 1, 2012

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