Commentary

A novel adjuvant Ling Zhi-8 for cancer DNA vaccines

Volume 7, Issue 11   November 2011
Pages 1161 - 1164
http://dx.doi.org/10.4161/hv.7.11.17753
Keywords: DNA vaccine, LZ-8, adjuvant, cancer, dendritic cell, fungal immunomodulatory protein
Authors: Ching-Liang Chu, Dz-Chi Chen and Chi-Chen Lin

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Abstract:
DNA vaccines have a wide range of applications, with several potential advantages compared to other vaccine technologies for diseases. No DNA vaccine has yet been licensed in humans; however, a lot of effort has been made to enhance their potential as human vaccines and therapeutics. Finding an effective adjuvant is a strategy to improve the efficacy of DNA vaccines. We recently identified a fungal immunomodulatory protein Ling Zhi-8 (LZ-8) with stimulatory activity on dendritic cells (DCs) that significantly increases the efficacy of a cancer DNA vaccine in a preclinical tumor model, suggesting that LZ-8 may be a good candidate adjuvant for vaccine development. Here we discuss the possibility for applying LZ-8 to a cancer DNA vaccine for humans.

Received: August 8, 2011; Accepted: August 14, 2011

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