Special Focus Review
Volume 7, Issue 11
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Pages 1192 - 1197http://dx.doi.org/10.4161/hv.7.11.17017
: Schistosomiasis, Sm-p80, calpain, neglected tropical disease (NTD), protective immunity, vaccines
Authors: Afzal A. Siddiqui, Bilal A. Siddiqui and Lisa Ganley-Leal View affiliations
Schistosomiasis is a major neglected tropical disease of public health importance to a billion people. An estimated 200 million people are currently infected; an additional 779 million individuals are at risk to acquire the infection in 74 countries. Despite many years of implementation of mass anti-parasitic drug therapy programs and other control measures, this disease has not been contained and continues to spread to new geographic areas. The discovery of a protective vaccine still remains the most potentially effective means for the control of this disease, especially if the vaccine provides long-term immunity against the infection. A vaccine would contribute to the reduction of schistosomiasis morbidity through induced immune responses leading to decrease in parasite load and reduced egg production. This vaccine could be administered to children between the ages of 3 and 12 years to prevent severe infection in a particularly high risk population. This review summarizes the current status of schistosomiasis vaccine development.
Received: June 18, 2011; Accepted: July 18, 2011