Review

Recent developments for Pseudomonas vaccines

Volume 7, Issue 10   October 2011
Pages 999 - 1011
http://dx.doi.org/10.4161/hv.7.10.16369
Authors: Anurag Sharma, Anja Krause and Stefan Worgall

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Abstract:
Infections with Pseudomonas aeruginosa are a major health problem for immune-compromised patients and individuals with cystic fibrosis. A vaccine against
P. aeruginosa has long been sought after, but is so far not available. Several vaccine candidates have been assessed in experimental animals and humans, which include sub-cellular fractions, capsule components, purified and recombinant proteins. Unique characteristics of the host and the pathogen have complicated the vaccine development. This review summarizes the current state of vaccine development for this ubiquitous pathogen, in particular to provide mucosal immunity against infections of the respiratory tract in susceptible individuals with  cystic fibrosis.

Received: May 6, 2011; Accepted: July 18, 2011

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