σ70 and PhoB activator: Getting a better grip
Volume 3, Issue 4
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Pages 160 - 164http://dx.doi.org/10.4161/trns.20444
: PhoB, RNA polymerase σ70
, X-ray crystal structure, transcription activation, two-component signal transduction
Authors: Albert Canals, Alexandre G. Blanco and Miquel Coll View affiliations
Transcription factors modulate gene expression by distinct, barely understood mechanisms. The crystal structure of a bacterial transcription subcomplex comprising the effector domain of factor PhoB, its target DNA and the σ4 domain of the RNA polymerase σ70 subunit supports the notion that a stronger grip on the promoter-factor complex results in an enhanced RNAP architecture.
Received: February 1, 2012; Accepted: April 19, 2012; Published Online: July 1, 2012
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