Point-of-View
σ70 and PhoB activator: Getting a better grip
Purchase or Subscribe
Pages 160 - 164
http://dx.doi.org/10.4161/trns.20444
Keywords: PhoB, RNA polymerase σ70, X-ray crystal structure, transcription activation, two-component signal transduction
Authors: Albert Canals, Alexandre G. Blanco and Miquel Coll
View affiliations
Abstract:
Transcription factors modulate gene expression by distinct, barely understood mechanisms. The crystal structure of a bacterial transcription subcomplex comprising the effector domain of factor PhoB, its target DNA and the σ4 domain of the RNA polymerase σ70 subunit supports the notion that a stronger grip on the promoter-factor complex results in an enhanced RNAP architecture.
Received: February 1, 2012; Accepted: April 19, 2012; Published Online: July 1, 2012
Preview:
Full Text - Ahead of Print Available - Log in!
Advertisements
