Review

Synthetic in vitro transcription circuits

Volume 3, Issue 2   March/April 2012
Pages 87 - 91
http://dx.doi.org/10.4161/trns.19734
Keywords: DNA nanotechnology, Molecular computing, synthetic biology, transcription networks
Authors: Maximilian Weitz and Friedrich C. Simmel

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Abstract:
With the help of only two enzymes—an RNA polymerase and a ribonuclease—reduced versions of transcriptional regulatory circuits can be implemented in vitro. These circuits enable the emulation of naturally occurring biochemical networks, the exploration of biological circuit design principles and the biochemical implementation of powerful computational models.

Received: January 14, 2012; Accepted: February 16, 2012

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