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Prp19C and TREX: Interacting to promote transcription elongation 
and mRNA export

Volume 3, Issue 1   January/February 2012
Pages 8 - 12
http://dx.doi.org/10.4161/trns.3.1.19078
Keywords: Prp19 complex, TREX, mRNP biogenesis, transcription
Authors: Sittinan Chanarat, Cornelia Burkert-Kautzsch, Dominik M. Meinel and Katja Sträßer

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Abstract:
During transcription of protein coding genes by RNA Polymerase II the mRNA is processed and packaged into an mRNP. Among the proteins binding cotranscriptionally to the mRNP are mRNA export factors. One of the protein complexes thus coupling transcription to mRNA export is the TREX complex. However, despite the fact that TREX was identified and characterized about a decade ago, it had remained enigmatic how TREX is recruited to genes. The conserved Prp19 complex (Prp19C) has long been known for its function in splicing. We recently identified Prp19C to be essential for a second step in gene expression namely TREX occupancy at transcribed genes, answering this long-standing question but also raising new ones.

Received: October 21, 2011; Accepted: December 15, 2011

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