Review

CHD chromatin remodelers and the transcription cycle

Volume 2, Issue 6   November/December 2011
Pages 244 - 253
http://dx.doi.org/10.4161/trns.2.6.17840
Authors: Magdalena Murawska and Alexander Brehm

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Abstract:
It is well established that ATP-dependent chromatin remodelers modulate DNA access of transcription factors and RNA polymerases by "opening" or "closing" chromatin structure. However, this view is far too simplistic. Recent findings have demonstrated that these enzymes not only set the stage for the transcription machinery to act but are actively involved at every step of the transcription process. As a consequence, they affect initiation, elongation, termination and RNA processing. In this review we will use the CHD family as a paradigm to illustrate the progress that has been made in revealing these new concepts.

Received: August 5, 2011; Accepted: August 23, 2011

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