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Changing the STATus quo in T helper cells

Volume 2, Issue 4   July/August 2011
Pages 179 - 182
http://dx.doi.org/10.4161/trns.2.4.16614
Authors: Gretta L. Stritesky and Mark H. Kaplan

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Abstract:
STAT proteins are obligate promoters of T helper cell differentiation and initial studies suggested that activation of a single STAT protein resulted in a particular phenotype. More recent work has supported a more complex paradigm wherein the activation of several STAT proteins is required for differentiation to a single effector lineage.

Received: April 29, 2011; Accepted: May 25, 2011

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