Report

No human protein is exempt from bacterial motifs, not even one

Volume 1, Issue 4   October/November/December 2010
Pages 328 - 334
http://dx.doi.org/10.4161/self.1.4.13315
Authors: Brett Trost, Guglielmo Lucchese, Angela Stufano, Mik Bickis, Anthony Kusalik and Darja Kanduc

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Abstract:
The hypothesis that mimicry between a self and a microbial peptide antigen is strictly related to autoimmune pathology remains a debated concept in autoimmunity research. Clear evidence for a causal link between molecular mimicry and autoimmunity is still lacking. In recent studies we have demonstrated that viruses and bacteria share amino acid sequences with the human proteome at such a high extent that the molecular mimicry hypothesis becomes questionable as a causal factor in autoimmunity. Expanding upon our analyses, here we detail the bacterial peptide overlapping to the human proteome at the penta-, hexa-, hepta-, and octapeptide levels by exact peptide matching analysis, and demonstrate that

Received: July 12, 2010; Accepted: August 11, 2010

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