Micromanipulating cancer: microRNA-based therapeutics?

Volume 6, Issue 3 July/August 2009
Pages 335 - 340
http://dx.doi.org/10.4161/rna.6.3.9013

Fabio Petrocca and Judy Lieberman

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Because microRNAs regulate cancer cell differentiation, proliferation, survival, and metastasis, manipulating microRNA function, either by mimicking or inhibiting miRNAs implicated in cancer, could provide a powerful therapeutic strategy to interfere with key pathways for cancer progression. This review will explore some of the opportunities and obstacles to harnessing microRNA biology for cancer therapy.