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Special Focus: Therapeutic RNAs

Micromanipulating cancer: microRNA-based therapeutics?

Fabio Petrocca and Judy Lieberman
Volume 6, Issue 3
July/August 2009
Pages 335 - 340
DOI: 10.4161/rna.6.3.9013

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Because microRNAs regulate cancer cell differentiation, proliferation, survival, and metastasis, manipulating microRNA function, either by mimicking or inhibiting miRNAs implicated in cancer, could provide a powerful therapeutic strategy to interfere with key pathways for cancer progression. This review will explore some of the opportunities and obstacles to harnessing microRNA biology for cancer therapy.


Authors

Fabio Petrocca
Immune Disease Institute, Program in Cellular and Molecular Medicine, Children’s Hospital Boston and Department of Pediatrics, Harvard Medical School
Judy Lieberman Corresponding author: lieberman@idi.harvard.edu
Immune Disease Institute, Program in Cellular and Molecular Medicine, Children’s Hospital Boston and Department of Pediatrics, Harvard Medical School

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