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Transcriptional control of microRNA expression in C. elegans: Promoting better understanding
Michael J. Turner and Frank J. Slack
Volume 6, Issue 1January/February/March 2009
Pages 49 - 53
DOI: 10.4161/rna.6.1.7574
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Transcriptional regulation of microRNA (miRNA) expression is one of the least understood aspects of miRNA biogenesis. In C. elegans the list of miRNAs whose transcriptional control has been described in some detail is currently limited to four: let-7, lin-4, lsy-6, and mir-61. Each of these genes has been shown experimentally to be transcriptionaly regulated by cis- and/or trans-acting factors that either promote or inhibit expression. Additionally, computational methods based on conservation among miRNA genes have yielded predicted regulatory sequences in C. elegans that may function to regulate miRNA expression on a genome-wide scale.
Authors
- Michael J. Turner Corresponding author: michael.turner@yale.edu
- Department of Molecular, Cellular and Developmental Biology; Yale University; New Haven, Connecticut USA
- Frank J. Slack
- Department of Molecular, Cellular and Developmental Biology; Yale University; New Haven, Connecticut USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF
If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
