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The current understanding of Ded1p/DDX3 homologs from yeast to human
Woan-Yuh Tarn and Tien-Hsien Chang
Volume 6, Issue 1January/February/March 2009
Pages 17 - 20
DOI: 10.4161/rna.6.1.7440
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DExD/H-box RNA helicases are involved in almost all steps of the eukaryotic mRNA biogenesis. The DEAD-box protein Ded1p/DDX3 is conserved from yeast to human. Various lines of genetic and biochemical evidence have indicated a role of the yeast Ded1p in translation and, most likely, in precursor mRNA splicing as well. In contrast, although recent studies have begun to reveal the function of the mammalian DDX3 in translation control, its exact role remains vague and even controversial. Here, we review these findings and particularly discuss the functional aspects of Ded1p/DDX3 in translation control.
Authors
- Woan-Yuh Tarn
- Institute of Biomedical Sciences; Academia Sinica; Nankang, Taipei Taiwan
- Tien-Hsien Chang
- Department of Molecular Genetics; Ohio State University; Columbus, Ohio USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF
If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
