Recommend RNA Biology to your librarian for 2008. Download form here.
Sign up for Table of Contents Alerts!
Email this page
Print this page
Point of View
ZAP-mediated mRNA degradation
Yiping Zhu and Guangxia Gao
volume 5 | issue 2
april/may/june 2008Pages: 65 - 67
Subscribe to this journal for $59/year
The zinc-finger antiviral protein (ZAP) is a host factor that inhibits the replication of many viruses by preventing the accumulation of viral mRNAs in the cytoplasm. ZAP specifically binds to the viral mRNA and recruits the cellular RNA degradation machinery to degrade the target RNA. In this article, we will review the work to date in understanding the mechanisms by which ZAP promotes viral mRNA decay and discuss future research directions to further investigate the function and underlying mechanisms of ZAP.
Authors
Yiping Zhu
Center for Infections and Immunity; Institute of Biophysics; Chinese Academy of Sciences; Beijing, China
Guangxia Gao
Center for Infections and Immunity; Institute of Biophysics; Chinese Academy of Sciences; Beijing, China