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Point of View
microRNA-Mediated Silencing Inside P Bodies
Shih-Peng Chan and Frank J. Slack
volume 3 | issue 3
july/august/september 2006Pages: 97 - 100
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Cytoplasmic processing bodies, or P bodies, contain a high concentration of enzymes and factors required for mRNA turnover and translational repression. Recent studies provide evidence that mRNAs silenced by miRNAs are localized to P bodies for storage or degradation, perhaps in adjacent subcompartments. mRNP remodeling, induced potentially by miRISC or RNA helicase activity, may cause the replacement of the translation initiation complex at the 5’ end of mRNA, translational repression, and localization to P bodies. Further remodeling may facilitate access of the decapping complex to the cap structure. However, with appropriate signals, stored mRNAs in P bodies could be released and returned to the translational machinery through a mechanism that may require binding of regulatory proteins to the 3’ UTR of selected mRNAs.
Authors
Shih-Peng Chan
Yale University; New Haven CT, USA
Frank J. Slack
Yale University; New Haven, CT
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.