Recommend RNA Biology to your librarian for 2008. Download form here.
Sign up for Table of Contents Alerts!
Email this page
Print this page
Research Paper
The Prokaryotic Origin of the Pathways for Synthesis and Post-Synthetic Modification of Deoxyribonucleic Acid
Tiziana Duranti, Anna La Teana, Tiziana Cacciamani and Pietro Volpe
volume 3 | issue 1
january/february/march 2006Pages: 49 - 53
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
A previous study showed that in mammals the pathways leading to synthesis and post-synthetic modification of DNA employ methionine as common donor of atoms: the carbon coming from the methyl group of this amino acid is needed for replication; its entire methyl group is needed to build m5C on semiconservatively newly replicating chains. This work showed that the two pathways originate in bacteria where an enzymatic system forms, on DNA, m6A in addition to m5C. The formation rate of m6A gradually decreased during the bacterial CGC, while that of m5C reached an optimum in its middle. This shift suggested that the dcm and dam methyltransferase activities, as well as the activities of the methyltransferase moieties of the RM enzymes, are uncoupled.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.