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Research Paper
Evidence for Control of Splicing by Alternative RNA Secondary Structures in Dipteran Homothorax Pre-mRNA
Evgeny A. Glazov, Michael Pheasant, Satu Nahkuri and John S. Mattick
volume 3 | issue 1
january/february/march 2006Pages: 36 - 39
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In a recent study that identified highly evolutionary conserved sequences in three genomes of Diptera species we described an ultraconserved element found at an internal exon-intron junction of the Drosophila melanogaster homothorax (hth) gene that appeared to be involved the control of hth pre-mRNA splicing. We also discussed a possible role of RNA secondary structure at this site in the regulation of the hth pre-mRNA splicing. In this report we identify a shorter evolutionary conserved intronic element within the hth gene that is located downstream of the first element and has sequence complementarity to it. We demonstrate that intramolecular interactions between these two elements would give rise to alternative RNA secondary structures, which in turn may result in differential control of the homothorax pre-mRNA splicing. We also provide additional comparative genomic data from several newly available insect genomes supporting our original conclusion that these conserved elements are important in the post-transcriptional regulation of homothorax gene expression in Diptera.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.