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Review
A-to-I RNA Editing and Human Disease
Stefan Maas, Yukio Kawahara, Kristen M. Tamburro and Kazuko Nishikura
volume 3 | issue 1
january/february/march 2006Pages: 1 - 9
This is an open-access article
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The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information. As the molecular players of editing are characterized and an increasing number of genes become identified that are subject to A-to-I modification, the potential impact of editing on the etiology or progression of human diseases is realized. Here we review the recent knowledge on where disturbances in A-to-I RNA editing have been correlated with human disease phenotypes.
This is an open-access article
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.